Hemophilia is usually inherited

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It is a rare bleeding disorder in which blood does not clot (coagulate) normally. If you suffer from hemophilia, in case of injury you will lose more amount of blood to others. Also, you may have internal bleeding, especially in the knees, ankles and elbows. This bleeding can damage organs and tissues and can endanger life.
BASIC KNOWLEDGE
Hemophilia is usually inherited (which means that the disorder passes from parents to children through genes). People born with hemophilia have little if any one of the clotting factors. This factor is a protein necessary for blood clots, which cooperates with the blood platelets (platelets) in the blood clotting process.
Two main types of hemophilia are Hemophilia A and Hemophilia B. If it is the former, then you lack of clotting factor VIII, and if you have a second, then you lack or have very little clotting factor IX.
Rarely hemophilia can be acquired during life. This occurs when the body creates antibodies that attack the clotting factors in the blood.
Hemophilia usually occurs in males (with rare exceptions). About 1 in 5,000 males are born with hemophilia each year.

CAUSES
If you have inherited hemophilia, you are born with the disorder. This is due to a fault in one of the genes that determines how to produce clotting factor VIII or IX. These genes are located on chromosome X (Women have two X chromosomes, while males have one X chromosome and one Y).
The man who has ‘found guilty’ for hemophilia X chromosome will have hemophilia, and women must have ‘found guilty’ on both X chromosomes to have hemophilia, which is very rare.
If the woman has ‘found guilty’ on one X chromosome, it is “carrier of hemophilia” – means that there can be affected by hemophilia, but is able to inherit her children ‘found guilty’ for hemophilia. A woman may be born with hemophilia only when the father is suffering from hemophilia, while her mother is carrying.
The main signs of hemophilia are massive bleeding and scarring easy. The bleeding may be external and internal.
Signs of external bleeding:
Bleeding in the mouth by a bite or tooth falling
Bleeding from the nose for no reason
Major bleeding from a small cut
Recurrence of bleeding after having stopped for a short time
Signs of internal bleeding:
Blood in the urine (due to bleeding in the kidneys and bladder)
Blood in the stools (due to bleeding in the stomach or intestine)
Bruising (due to bleeding in the large muscles of the body)
Bleeding in the knees, elbows or other joints is another common form of internal bleeding in people suffering from hemophilia. Initially bleeding in the joints does not cause pain or obvious signs, but then the node swells, is hot to the touch and hurt during movement. With the continuation of bloodshed continues swelling, and movement is impossible and the pain can be overwhelming. In case of non-intervention rapid node can be seriously damaged.
Internal bleeding in the brain is a serious complication of hemophilia that can happen from a slight head clash. Signs and symptoms of bleeding in the brain are:
Long headaches and severe neck pain
Repeated vomiting
Sleepiness or changes in behavior
Sudden weakness or indolence in the hands and feet or problems walking
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Convulsions or dizziness.
TREATMENT
Replacement Therapy
The main treatment of hemophilia is called replacement therapy. Concentrates of clotting factor VIII (for hemophilia A) or clotting factor IX (for hemophilia B) are provided in order to replace the missing factor. Preventive therapy may be given regularly, or as needed given only in the event of bleeding. The second is less intensive and less expensive than the first, but there is a risk that bleeding cause damage before you to get therapy.
Complications of replacement therapy are:
Development of antibodies that attack coagulation factor
Development of viral infections of human coagulation factors
Damage to joints, muscles or other parts of the body that comes as a result of delayed treatment
Other forms of treatment
Desmopressin (DDAVP) – is a hormone used to treat people who have hemophilia slight or moderate type A (not used in hemophilia B or severe forms of hemophilia A).

Therapy genes – scientists are trying to find ways to correct the guilty genes that cause hemophilia. However, this therapy is not yet developed to the extent that is acceptable..
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